Han Xiao
  • Associate Professor
  • E-mail: smallhanx@163.com
  • Tel: 021-34206350
    • State Key Lab of Microbial Metabolism, and Department of Bioengineering, School of Life Sciences & Biotechnology

    Professional Experience

    • 2015.2-present  Associate Professor, State Key Lab. of Microbial Metabolism, and Department of Bioengineering, School of Life Sciences & Biotechnology, SJTU
    • 2012.8-2015.1  Postdoctoral Associate, Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA


    Research Interests

    • Metabolic Engineering
    • Genome Engineering
    • Synthetic Biology


    Honors & Awards

    • Poster Award, 4th Annual Postdoctoral Research Symposium, UIUC, 2014
    • Third Prize of Innovation Cup among University Students in Shanghai, 2012
    • Outstanding University Graduate of Sichuan Agricultural University, 2007
    • Overall Quality of University A-level Certificate in Sichuan Province, 2006
    • Silver Award of the Business Plan Competition of Challenge Cup in Sichuan Province, 2006



    • 2014

    1.  T Si, H Xiao (co-first author) and HM Zhao. Rapid prototyping of a microbial cell factory via genome scale engineering. Biotechnol. Adv., 2014. DOI: 10.1016/j.biotechadv.2014.11.007.

    2.  H Xiao, ZH Bao and HM Zhao. High throughput screening and selection methods in directed enzyme evolution. Ind. Eng. Chem. Res., 2014. DOI: 10.1021/ie503060a.

    3.   ZH Bao, H Xiao (co-first author), J Liang, L Zhang, X Xiong, N Sun, T Si and HM Zhao. Homology-Integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae. ACS Synth. Biol., 2014. DOI: 10.1021/sb500255k.

    4.  H Xiao, ZY Shao, Y Jiang, S Dole and HM Zhao. Exploiting Issatchenkia orientalis SD108 for succinic acid production. Microb. Cell Fact., 2014. DOI: 10.1186/s12934-014-0121-4.

    5.   H Xiao and HM Zhao. Genome-wide RNAi screen reveals the E3 SUMO-protein ligase gene SIZ1 as a novel determinant of furfural tolerance in Saccharomyces cerevisiae. Biotechnol. Biofuels, 2014. DOI: 10.1186/1754-6834-7-78. 

    6.   T Si, YZ Luo, H Xiao and HM Zhao. Utilizing an endogenous pathway for 1-butanol production in Saccharomyces cerevisiae. Metab. Eng., 2014. DOI: 10.1016/j.ymben.2014.01.002. Epub 2014 Jan 9.

    • 2013

    1.  ZL Li, H Xiao (co-first author), WH Jiang, Y Jiang and S Yang. Improvement of butanol production from xylose mother liquor by engineering the xylose metabolic pathway in Clostridium acetobutylicum EA 2018. Appl. Biochem. Biotechnol., 2013. DOI: 10.1007/s12010-013-0414-9.

    • 2012

    1. H Xiao, ZL Li, Y Jiang, YL Yang, WH Jiang, Y Gu and S Yang. Metabolic engineering of d-xylose pathway in Clostridium beijerinckii to optimize solvent production from xylose mother liquid. Metab. Eng., 2012, 14(5): 569-578. 

    • 2011

    1. H Xiao, Y Gu, YY Ning, YL Yang, WJ Mitchell, WH Jiang and S Yang. Confirmation and elimination of xylose-metabolic bottlenecks in glucose-PTS-deficient Clostridium acetobutylicum to realize simultaneous utilization of glucose, xylose and arabinose. Appl. Environ. Microbiol., 2011, 77(22): 7886-7895.

    2.  Y Gu, Y Jiang, H Wu, XD Liu, ZL Li, J Li, H Xiao, ZB Shen, HJ Dong, YL Yang, Y Li, WH Jiang and S Yang (2011). Economical challenges to microbial producers of butanol: Feedstock, butanol ratio and titer. Biotechnol. J., 2011, 6(11): 1348-1357.

    • 2010

    1.  JJ Yang, WC Fan, H Xiao, CH Guan, CZ Cao, HF Shao, WH Jiang and S Yang. Genome shuffling method of Bacillus Subtilis. Sheng Wu Gong Cheng Xue Bao, 2010, 26(10): 1385−1392. (Chinese)

    2.  Y Gu, Y Jiang, H Wu, XD Liu, ZL Li, J Li, H Xiao, ZB Shen, JB Zhao, YL Yang, WH Jiang and S Yang. Current status and prospects of biobutanol manufacturing technology. Sheng Wu Gong Cheng Xue Bao, 2010, 26(7): 914-923. (Chinese, which is awarded as the outstanding paper by Sheng Wu Gong Cheng Xue Bao in 2013).



    1.      Y Gu, H Xiao, YY Ning, S Yang, WH Jiang, ZL Li, Z Sun. A method of improving sugar consumption of Clostridium acetobutylicum in mixed sugars fermentation. Chinese patent. 201210163123.8.

    2.     S Yang, H Xiao, Y Gu, ZL Li, Y Jiang, WH Jiang. A method of improving d-xylose consumption of Clostridium beijerinckii. Chinese patent. 201310147888.7.



    • 2007.9-2012.6  Ph.D. Key Lab. of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.
    • 2003.9-2007.6  B.S. Biological Science, College of Life and Basic Sciences, Sichuan Agricultural University, China.


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